Leishmaniasis: effect of enalaprilat on the production of (ON) and cytokines in vitro

Leishmaniasis is neglected diseases; the drugs used have significant toxic effects that compromise patient compliance, and increased loss of efficacy due to resistant infectious strains. Assays on Swiss mice infected with Leishmania brasiliensis treated Angiotensin-Suppressing Enzyme (ACE) inhibitors showed that, in addition classical cardiovascular system, some these had nonhemodynamic, immunomediated functions such as cytokine production. In this study, effect enalaprilate nitric oxide (NO) production cytokines were evaluated, i.e., interleukins-10 12 IFN-γ J774 A.1 macrophages by braziliensis. Enalaprilate demonstrated vitro immunomodulatory capacity, increasing release NO induce IL-12 also decreasing il-10 release.